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Synthesis of novel vitamin C phosphodiesters: stability and antioxidant activity
1Department of Applied Chemistry, Faculty of Engineering, Ehime University, Japan.
Carbohydrate Research
|June 5, 1996
Abstract:
A novel series of hybrid L-ascorbic acid (vitamin C) phosphodiesters linked at the C-2 hydroxyl group with other biologically active substances, namely myo-inositol, arbutin, 4-hydroxy-L-proline, and glycolic acid were synthesized, and their thermal stability and reducing activity against free radicals were estimated in vitro. All of the phosphodiesters exhibited high thermal stabilities; however, their antioxidant activities in vitro were generally lower than that of vitamin C.