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Leptomeningeal fibroma
J E Mooney1, S C Papasozomenos
1Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, TX 77225, USA.
Clinical Neuropathology
|March 1, 1996
Summary
This study details a rare benign fibrous tumor of the leptomeninges, a membrane surrounding the brain and spinal cord. The tumor exhibited unusual protein expression, suggesting a unique origin or environmental influence within the central nervous system.
Area of Science:
- Neuropathology
- Central Nervous System Tumors
- Fibrous Tumors
Background:
- Benign fibrous tumors of the central nervous system (CNS) are infrequently documented.
- Only one prior case of a CNS fibrous tumor adjacent to the leptomeninges has been reported in the literature.
- The histogenesis and immunophenotypic characteristics of such lesions remain poorly understood.
Observation:
- A case of a fibroma arising from the leptomeninges is presented.
- The tumor demonstrated low cellularity and areas of calcification.
- Electron microscopy confirmed typical fibroma features.
Findings:
- Immunophenotyping revealed unexpected positivity for S-100 protein and glial fibrillary acidic proteins (GFAP).
- These findings differ from typical presentations of intracranial fibrous tumors.
- The observed tumor more closely resembled extracranial fibromas.
Implications:
- The unusual immunophenotype suggests a possible pluripotential cell of origin or antigen expression induced by the CNS microenvironment.
- This case expands the understanding of the spectrum of benign fibrous tumors in the CNS.
- Further research is needed to determine the incidence and precise histogenesis of leptomeningeal fibromas.