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Design of crossover microcomputer program and application on drug bioequivalence data

M E Abdullah1, Y M El-Sayed

  • 1Department of Pharmaceutics, King Saud University, Saudi Arabia.

Computer Methods and Programs in Biomedicine
|December 1, 1995
PubMed
Summary

A new BASIC program simplifies drug bioequivalence studies. It effectively compared ibuprofen bioavailability when taken alone versus with colestipol or cholestyramine.

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Area of Science:

  • Pharmacokinetics
  • Biostatistics
  • Computer Science

Background:

  • Drug bioequivalence studies are crucial for pharmaceutical development.
  • Statistical analysis is essential for interpreting pharmacokinetic data.
  • Accessible computational tools can aid researchers in these fields.

Purpose of the Study:

  • To introduce a simple microcomputer program for drug bioequivalence analysis.
  • To demonstrate the program's utility in comparing drug bioavailability.
  • To facilitate statistical investigation in related scientific areas.

Main Methods:

  • Development of a crossover program using BASIC language.
  • Application of the program to analyze ibuprofen bioavailability.
  • Comparison of pharmacokinetic profiles under different administration scenarios.

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Main Results:

  • The program successfully facilitated the comparison of drug bioavailability.
  • Ibuprofen bioavailability was assessed when administered alone.
  • The impact of colestipol hydrochloride and cholestyramine on ibuprofen bioavailability was evaluated.

Conclusions:

  • The developed BASIC program is a valuable tool for drug bioequivalence studies.
  • The program provides a straightforward method for statistical investigation.
  • It aids in understanding drug interactions and pharmacokinetic variations.