Fabrication of a keratoprosthesis

Area of Science:

• Ophthalmology
• Biomaterials Science
• Medical Device Engineering

Background:

• Corneal opacity significantly impairs vision, often rendering conventional corneal transplantation unsuitable.
• Keratoprostheses serve as artificial corneas, providing a potential solution for severe corneal blindness.
• Polymethylmethacrylate (PMMA) is a durable and optically clear material suitable for intraocular devices.

Purpose of the Study:

• To describe the design, fabrication, and optical performance of two novel PMMA keratoprosthesis variations.
• To evaluate the suitability of different keratoprosthesis designs for specific ocular surface conditions.
• To offer a viable alternative for patients with opaque corneas and poor prognosis for standard transplants.

Main Methods:

• Detailed design specifications for two PMMA keratoprosthesis types were developed.
• Fabrication processes for the described PMMA devices were outlined.
• Optical testing methodologies were employed to assess the visual performance of the keratoprostheses.

Main Results:

• Two distinct PMMA keratoprosthesis designs were successfully created and optically tested.
• Type 1: A twin-plate collarbutton design for eyes with adequate tear production.
• Type 2: A modified design with an anterior cylinder for end-stage dry eyes with closed eyelids.

Conclusions:

• PMMA keratoprostheses represent a promising approach for vision restoration in complex corneal diseases.
• The described designs cater to different ocular surface environments, enhancing applicability.
• These devices offer hope for usable vision in patients with limited conventional treatment options.