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Changes in human skeletal muscle contractile function following stimulated eccentric exercise

S J Brown1, R B Child, A E Donnelly

  • 1School of Health Sciences, University of Wolverhampton, UK.

European Journal of Applied Physiology and Occupational Physiology
|January 1, 1996
PubMed
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Eccentric exercise causes delayed muscle soreness and reduced force, impairing muscle response to electrical stimulation. This suggests damage delays nerve signal transmission, not muscle relaxation mechanisms.

Area of Science:

  • Exercise Physiology
  • Muscle Physiology
  • Biophysics

Background:

  • Eccentric exercise, involving muscle lengthening under load, is known to cause muscle damage and soreness.
  • Understanding the impact of eccentric exercise on neuromuscular function is crucial for rehabilitation and training.

Purpose of the Study:

  • To investigate the time course of changes in human skeletal muscle contractile function after eccentric exercise.
  • To determine the effects of eccentric exercise on the response to percutaneous electrical myostimulation (PES).

Main Methods:

  • Nine subjects underwent percutaneous electrical myostimulation (PES) to evoke knee extensor muscle actions.
  • Measurements included indices of contractile function, delayed onset muscle soreness (DOMS), and serum creatine kinase activity for up to 9 days postexercise.

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Main Results:

  • DOMS, elevated creatine kinase, and reduced force production were observed postexercise.
  • A significant delay in the onset of contraction following 100 Hz PES was noted immediately and 3 days postexercise.
  • Muscle relaxation rates and specific contraction/relaxation time constants remained unaffected.

Conclusions:

  • Eccentric exercise impairs skeletal muscle contractile function, evidenced by delayed responses to electrical stimulation.
  • The observed delay in excitation-contraction coupling likely results from damage-induced alterations in action potential propagation.
  • Sarcoplasmic reticulum function appears intact, suggesting it is not the primary site of contractile failure post-eccentric exercise.