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SNAP-25 is present on chromaffin granules and acts as a SNAP receptor
M Tagaya1, T Genma, A Yamamoto
1School of Life Science, Tokyo University of Pharmacy and Life Science, Japan.
FEBS Letters
|September 23, 1996
Abstract:
SNAP-25 is located on the plasma membrane and essential for exocytosis of neurotransmitters. It was suggested that SNAP-25 and syntaxin 1 via the interaction with VAMP-2 located on synaptic vesicles mediate the docking of the vesicles with the plasma membrane. In the present study, by means of biochemical and morphological analyses, we showed that SNAP-25 is present on chromaffin granules as well as on the plasma membrane. Reconstitution and immunoprecipitation analyses revealed that SNAP-25 on chromaffin granules has essentially the same properties as does SNAP-25 on the plasma membrane.