Related Experiment Video
Updated: Aug 12, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
[Review: hybrid designs of cohort studies and case control studies]
M Delgado-Rodríguez1, M Sillero
1Cátedra de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Cantabria, Santander.
Abstract:
Hybrid epidemiologic designs combining elements from case-control studies and cohort studies are reviewed. Firstly, the characteristics of selection of both index group and reference group are commented on. The selection of cases required a population-based disease registry. The type of selection of reference group permits to identify the main hybrid designs: the case-cohort approach, sampling from the base at the beginning of risk period, and the nested (within a cohort) case-control studies, usually with a matched density sampling. The assumptions needed for estimating without bias relative risk or rate ratio via odds ratio and without needing the condition of disease rarity are revised. Advantages, uses, and drawbacks are summarized. Lastly, general guidelines for the analysis of these designs are displayed.
Related Concept Videos
Study Design in Statistics
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
Crossover Experiments
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs
Introduction to Epidemiology
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
