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Radiotherapy of oral malignant melanomas in dogs
1Queen's Veterinary School Hospital, University of Cambridge, England.
Objective:
To evaluate response to radiotherapy in dogs with oral malignant melanomas.
Design:
Clinical trial.
Animals:
36 dogs with histologically confirmed oral malignant melanomas.
Procedure:
The prescribed radiation dose was 36 Gy given in 4 fractions of 9 Gy at 7-day intervals. The primary radiation source was a linear accelerator.
Results:
In 25 of 36 dogs, complete remission was achieved, and in 9 dogs, partial remission was achieved. Recurrence of the primary tumor was the cause of euthanasia of 4 dogs. Twenty-one dogs were euthanatized because of metastasis.
Clinical Implications:
Radiotherapy was an effective palliative treatment for the primary tumor in dogs with oral malignant melanomas. However, rapid development of metastatic disease remained a major challenge.
