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Updated: Aug 13, 2026

Establishment of a Rat Model of Superior Sagittal-Sinus Occlusion via a Thread-Embolism Method
Published on: July 4, 2021
Puerperal cerebral venous thrombosis associated with decreased free protein S: a case report
H L Galan1, A B McDowell, P R Johnson
1Department of Obstetrics and Gynecology, Scott & White Clinic and Memorial Hospital, Texas A & M University Health Science Center, College of Medicine, Temple 76508, USA.
Background:
Cerebral venous thrombosis is a rare event with multiple risk factors. This condition can be associated with a hypercoagulable state, such as that seen with dysfunctional or decreased plasma protein C and protein S. Both plasma proteins are naturally occurring, vitamin K-dependent anticoagulants that are important for regulation of the clotting cascade.
Case:
A postpartum patient presented with complaints of a severe headache and hypertension and later developed status epilepticus. She was found to have superior sagittal sinus and right internal jugular vein thrombosis and protein S deficiency.
Conclusion:
The combination of protein S deficiency and the further reduction due to pregnancy may enhance the risk of major thrombotic episodes in the peripartum period.
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