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[Chronic idiopathic hypertransaminasemia]

L Zancan1, T Bettiol, A Rini

  • 1Dipartimento di Pediatria, Università degli Studi, Padova.

Minerva Pediatrica
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

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Pediatric idiopathic hypertransaminasemia often shows mild aminotransferase elevations. Liver biopsy is recommended for diagnosis, revealing metabolic issues in most children, guiding further investigation.

Area of Science:

  • Pediatric Gastroenterology and Hepatology
  • Clinical Biochemistry
  • Diagnostic Pathology

Background:

  • Elevated aminotransferase serum levels are common in children.
  • Idiopathic hypertransaminasemia lacks a clear cause in many pediatric cases.
  • Understanding the underlying etiology is crucial for appropriate management.

Purpose of the Study:

  • To retrospectively evaluate clinical patterns of chronic idiopathic hypertransaminasemia in children.
  • To assess the diagnostic utility of various investigations, including liver biopsy.
  • To identify underlying causes and guide diagnostic approaches.

Main Methods:

  • Retrospective analysis of 108 pediatric patients with chronic idiopathic hypertransaminasemia.
  • Data collected via questionnaires sent to 11 Italian Pediatric Centers.

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  • Review of clinical data, liver function tests, ultrasound, and liver histology where available.

    • Main Results:

    • Most patients were asymptomatic with mild aminotransferase elevations (rarely >5x normal).
    • Only 25.9% normalized levels during a 22-month follow-up; no clinical liver disease signs observed.
    • Liver histology in 46 patients revealed metabolic alterations (65%) more frequently than inflammation (13%).

    Conclusions:

    • Liver histology is informative in diagnosing idiopathic chronic hypertransaminasemia in children.
    • Metabolic alterations are common findings, suggesting a need for targeted investigations.
    • Histologic evaluation should be considered in the diagnostic workup for these patients.