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Related Experiment Videos

Increased potency of vanadium using organic ligands

J H McNeill1, V G Yuen, S Dai

  • 1Faculty of Pharmaceutical Sciences, Vancouver, B.C., Canada.

Molecular and Cellular Biochemistry
|December 6, 1995
PubMed
Summary

Bis(maltolato)oxovanadium(IV) (BMOV) effectively lowers blood glucose and lipids in diabetic rats with reduced dosage and toxicity compared to vanadyl sulfate. This organic vanadium compound shows promise for managing diabetes and its complications.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Endocrinology

Background:

  • Inorganic vanadium compounds show oral activity for lowering glucose in diabetes but have poor absorption.
  • Organic vanadium compounds have been synthesized to improve absorption and efficacy.
  • Bis(maltolato)oxovanadium(IV) (BMOV) is a promising organic vanadium compound for diabetes treatment.

Purpose of the Study:

  • To investigate the in vivo glucose-lowering effects of the organic vanadium compound BMOV in streptozotocin-diabetic rats.
  • To compare the efficacy and toxicity of BMOV with vanadyl sulfate (VS).
  • To evaluate the effectiveness of BMOV via oral, intraperitoneal, and intravenous administration routes.

Main Methods:

  • STZ-diabetic rats were treated with BMOV or VS via drinking water, oral gavage, intraperitoneal injection, or intravenous infusion.

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  • Plasma glucose and lipid levels were monitored over a 25-week period.
  • Efficacy was assessed by calculating ED50 values and observing euglycemic periods.
  • Toxicity was evaluated based on observed side effects.

    • Main Results:

    • BMOV significantly lowered plasma glucose and lipids in diabetic rats.
    • BMOV required approximately 50% of the maintenance dose compared to VS for similar effects.
    • BMOV demonstrated lower ED50 values than VS across different administration routes (oral, intraperitoneal).
    • Intravenous infusion of BMOV effectively reduced plasma glucose, while VS was ineffective.
    • No marked toxicity was observed with BMOV treatment, and secondary diabetes complications were prevented.

    Conclusions:

    • BMOV is a highly effective oral agent for lowering glucose and lipids in diabetic rats.
    • BMOV exhibits superior efficacy and potentially lower toxicity compared to inorganic vanadium compounds like VS.
    • BMOV's effectiveness across multiple administration routes, including oral and IV, highlights its therapeutic potential for diabetes management.