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[Viral hepatitis B and C in patients with acute leukemias]
Enzyme immunoassay has been used in 102 patients with acute leukemia (AL) and 340 donors to identify serological markers of hepatitis B virus (HBV) and hepatitis C virus (HCV): HB-sAg, anti-HBs, anti-HBc, anti-HBc IgM, HBeAg, anti-HBe. At the moment of AL diagnosis in 50 patients with acute myeloid leukemia and in 28 patients with acute lymphoblastic leukemia at least one HBV marker was found in 68% and 71%, respectively, HBsAg in 12% of patients with AML and 25% of those with ALL. In remission maintenance, HBsAg was registered in 83% of patients with AML and 44% of those with ALL. Anti-HCV in diagnosis of acute leukemia were detected in 1.28% of patients, 12 months after in 40% with ALL and 67% with AML. In examination of the donors at least one HBV marker was found in 36%, HBsAg in 2.1%, anti-HCV in 1.86% of the examinees. It is inferred that acute leukemia patients are often infected with HBV and in long-term follow-up demonstrate reactivation of viral infection, though infection with mutant B viruses is also possible. HCV is a main cause of posttransfusion hepatitis in this group of patients.
Enzyme immunoassay has been used in 102 patients with acute leukemia (AL) and 340 donors to identify serological markers of hepatitis B virus (HBV) and hepatitis C virus (HCV): HB-sAg, anti-HBs, anti-HBc, anti-HBc IgM, HBeAg, anti-HBe. At the moment of AL diagnosis in 50 patients with acute myeloid leukemia and in 28 patients with acute lymphoblastic leukemia at least one HBV marker was found in 68% and 71%, respectively, HBsAg in 12% of patients with AML and 25% of those with ALL. In remission maintenance, HBsAg was registered in 83% of patients with AML and 44% of those with ALL. Anti-HCV in diagnosis of acute leukemia were detected in 1.28% of patients, 12 months after in 40% with ALL and 67% with AML. In examination of the donors at least one HBV marker was found in 36%, HBsAg in 2.1%, anti-HCV in 1.86% of the examinees. It is inferred that acute leukemia patients are often infected with HBV and in long-term follow-up demonstrate reactivation of viral infection, though infection with mutant B viruses is also possible. HCV is a main cause of posttransfusion hepatitis in this group of patients.