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Esterase D polymorphism in several population groups in Israel

R Golan, J Ben-Ezzer, A Szeinberg

    Human Heredity
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Genetic polymorphism of red blood cell esterase D (EsD) varies significantly across Israeli populations. Ashkenazi and North African Jews exhibit lower EsD2 gene frequencies compared to Yemenite Jews and Arabs.

    Area of Science:

    • Genetics
    • Population Genetics
    • Biochemistry

    Background:

    • Esterase D (EsD) is an enzyme found in red blood cells.
    • Genetic variations in EsD can be used to study population genetics and migration patterns.

    Purpose of the Study:

    • To investigate the genetic polymorphism of red blood cell esterase D (EsD) in various population groups in Israel.
    • To analyze the distribution of EsD1 and EsD2 genes among these communities.

    Main Methods:

    • Blood samples were collected from 9 population groups in Israel, including different Jewish communities and Arabs.
    • Esterase D (EsD) gene frequencies (EsD1 and EsD2) were analyzed using population genetic methods.
    • Statistical analysis (chi-squared test) was performed to assess the homogeneity of gene distribution.

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    Main Results:

    • The distribution of EsD1 and EsD2 genes was found to be non-homogenous across the 9 investigated communities (chi2 = 42.3; p < 0.0005).
    • Significantly lower frequencies of the EsD2 gene were observed in Ashkenazi Jews (0.100) and North African Jews (0.102) compared to Yemenite Jews (0.212) and Israeli Arabs (0.206).
    • Intermediate EsD2 frequencies were found in other investigated communities, and a rare EsD2 allele was identified in a Greek Jewish family.

    Conclusions:

    • There are significant genetic differences in red blood cell esterase D (EsD) polymorphism among Israeli population groups.
    • The findings highlight distinct genetic profiles of Jewish and Arab populations in Israel regarding EsD gene distribution.
    • Further research into EsD variations can contribute to understanding population history and genetic diversity.