[The role of endothelin in coronary circulation]

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Updated: Nov 3, 2026

In Vitro Model of Coronary Angiogenesis
08:03

In Vitro Model of Coronary Angiogenesis

Published on: March 10, 2020

O Lisý1, J Vojácek

  • 1II. interní klinika 1. LF UK, Praha.

Vnitrni Lekarstvi
|June 1, 1996
PubMed

Insights

Endothelin, a key vasoconstrictor, impacts vascular tone and coronary function. Its role in endothelial damage and cardiovascular diseases like heart failure and myocardial infarction is significant.

Area of Science:

  • Cardiovascular Physiology
  • Endothelial Biology
  • Vascular Medicine

Context:

  • Endothelial cells produce endothelin, a potent vasoconstrictor crucial for vascular tonus.
  • Endothelial dysfunction disrupts the balance between vasoconstrictor and vasodilator substances.
  • Nitric oxide (NO) and endothelin are key players in maintaining vascular homeostasis.

Purpose:

  • To review the multifaceted roles of endothelin in cardiovascular physiology.
  • To elucidate the impact of endothelin on cardiomyocytes, cardiac conduction, and coronary arteries.
  • To highlight endothelin's involvement in various cardiovascular pathologies.

Summary:

  • Endothelin influences cardiomyocytes, cardiac conduction, and coronary artery function.
  • The review emphasizes endothelin's detrimental effects in atherosclerosis, hypercholesterolemia, and hypertension.
  • Endothelin is implicated in acute conditions such as unstable angina, cardiogenic shock, heart failure, and myocardial infarction.
  • The review concludes by examining the link between percutaneous transluminal coronary angioplasty and endothelin release.

Impact:

  • Provides a comprehensive overview of endothelin's physiological and pathological roles in the cardiovascular system.
  • Underscores the significance of endothelin in diverse cardiovascular diseases, offering insights for therapeutic targets.
  • Discusses the clinical implications of endothelin in conditions ranging from chronic diseases to acute cardiac events.

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