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[Isoniazid acetylation, its relation to genetic and environmental altitude factors]
G Taboada Lopez1, M L Navarro de Claure
1Instituto de Genética Humana, Facultad de Medicina, La Paz, Bolivia.
Archivos De Biologia Y Medicina Experimentales
|January 1, 1987
Abstract:
Since the discovery of isoniacid in 1952, it has become apparent that there are considerable variations in the manner in which individuals react to the drug. We studied 90 patients from La Paz (3.600 m. over sea level) and 50 patients from Santa Cruz (470 m. over sea level). Our results in the two groups tested suggest that the high altitude hypoxia increases the velocity of inactivation. Despite to the influence of hypoxia it was seen that both groups have the some frequency of rapid and slow inactivators.