Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immunomorphologic markers in breast cancer]

N N Volchenko, L V Litvinova, K K Pugachev

    Arkhiv Patologii
    |January 1, 1996
    PubMed
    Summary

    Immunohistochemical markers like PCNA and CEA show varied expression in mammary carcinoma (MC). While some markers correlate with tumor size and metastasis, clear links to histological type or malignancy grade were not found.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [HER2 status assessment in carcinomas of various localizations. A multicenter morphological study in the Russian Federation].

    Arkhiv patologii·2026
    Same author

    [Quality control of immunohistochemical studies in Russia in 2025: achievement and prospects].

    Arkhiv patologii·2026
    Same author

    [Classification of non-small cell lung cancer according to the WHO 2021: from morphology to personalized therapy].

    Arkhiv patologii·2026
    Same author

    [Immunophenotypic characteristics of mast cells in non-metastatic seminoma].

    Arkhiv patologii·2025
    Same author

    [Quality control of immunohistochemical studies: compulsory duty or urgent need?]

    Arkhiv patologii·2025
    Same author

    [Analysis of the work of the Immunohistochemical Quality Control Center of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia in 2023].

    Arkhiv patologii·2024

    Area of Science:

    • Oncology
    • Immunohistochemistry
    • Cancer Biology

    Context:

    • Mammary carcinoma (MC) encompasses diverse histological subtypes.
    • Immunohistochemistry is crucial for characterizing tumor markers.
    • Understanding tumor markers aids in prognosis and treatment strategies.

    Purpose:

    • To immunomorphologically study various mammary carcinoma subtypes.
    • To investigate the expression of proliferative cells nuclear antigen (PCNA), cerbB-2, carcinoembryonic antigen (CEA), trophoblastic beta 1 globulin (TBG), ferritin (Fe), and cyprein in MC.
    • To correlate marker expression with histological structure, malignancy grade, tumor size, and lymph node metastasis.

    Summary:

    • Immunohistochemical analysis revealed PCNA, cerbB-2, CEA, TBG, and Fe expression in a significant portion of MC cases.

    Related Experiment Videos

  • Cyprein was observed in approximately half of the cases.
  • No definitive correlation was found between immunomorphological parameters and histological type or malignancy grade.
  • PCNA expression increased with tumor size.
  • CEA, Fe, and TBG showed a tendency for more frequent observation in cases with lymph node metastases.

    • Impact:

    • Identifies potential prognostic indicators in mammary carcinoma.
    • Highlights the complex interplay of tumor markers, size, and metastasis.
    • Suggests specific marker combinations (e.g., CEA with TBG, PCNA, or cerbB-2) are associated with a less favorable prognosis.