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Lipids and stroke: a paradox resolved

V Hachinski1, C Graffagnino, M Beaudry

  • 1Department of Clinical Neurological Sciences, London Health Sciences Centre-University Campus, Ontario, Canada.

Archives of Neurology
|April 1, 1996
PubMed
Summary
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High LDL cholesterol and triglycerides are key risks for atherothrombotic stroke. Serum ferritin levels, however, do not correlate with cerebrovascular disease risk.

Area of Science:

  • Cardiovascular Science
  • Neurology
  • Clinical Biochemistry

Background:

  • Dyslipidemia is a known risk factor for coronary artery disease.
  • The link between dyslipidemia and ischemic cerebrovascular disease is less understood.
  • Stroke heterogeneity may obscure the relationship between lipid profiles and cerebrovascular events.

Purpose of the Study:

  • To investigate the association between lipid profiles and atherothrombotic cerebrovascular disease.
  • To determine if serum ferritin levels correlate with atherothrombotic cerebrovascular disease.

Main Methods:

  • A case-control study involving 90 patients with atherothrombotic stroke or transient ischemic attack (TIA) and 90 matched controls.
  • Measurement of serum lipids (total cholesterol, LDL, HDL, triglycerides), lipoprotein(a), apolipoprotein E phenotype, and serum ferritin.

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  • Comparison of these markers between patients and controls.

    • Main Results:

    • Significantly higher levels of total cholesterol, LDL cholesterol, and triglycerides in patients compared to controls.
    • Significantly lower levels of HDL cholesterol in patients.
    • No significant differences in lipoprotein(a), apolipoprotein E phenotype distribution, or serum ferritin levels between groups.

    Conclusions:

    • Elevated LDL cholesterol and triglyceride levels are independent risk factors for atherothrombotic cerebrovascular disease (stroke/TIA).
    • Serum ferritin levels do not appear to be associated with atherothrombotic cerebrovascular or coronary disease.