Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia
V J Kattapong1, W M Brooks, M H Wesley
1Department of Neurology, University of New Mexico School of Medicine, Albuquerque, USA.
Objective:
To identify biochemical differences in brain tissue between patients with dementia of the Alzheimer type and vascular dementia.
Design And Subjects:
Proton magnetic resonance spectroscopy was used to compare 10 patients with dementia of the Alzheimer type and 8 age-matched patients with vascular dementia.
Results:
The ratios of N-acetyl groups to creatine and N-acetyl groups to choline were lower in regions of subcortical white matter in patients with vascular dementia than in patients with dementia of the Alzheimer type (P < .02).
Conclusion:
Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.
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