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The development of the corpus callosum in semilobar and lobar holoprosencephaly
D Rubinstein1, A G Cajade-Law, V Youngman
1Department of Radiology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box A-034, Denver, CO 80262, USA.
Objective:
The objective of this study was to determine whether and how a true corpus callosum develops in milder cases of holoprosencephaly.
Materials And Methods:
The MR scans of seven patients with holoprosencephaly and a callosum-like structure were reviewed. The anatomy of the callosum-like structure and the pericallosal anatomy were evaluated.
Results:
Six of the seven cases had a posterior corpus callosum. The seventh case was indeterminate because lack of myelination prevented confirmation that the callosum-like structure consisted only of white matter. In each case the posterior corpus callosum formed posterior to white matter which spanned the interhemispheric fissure beneath a layer of cortical gray matter.
Conclusion:
A posterior corpus callosum can develop in holoprosencephaly because the first callosal axons use the white matter of the undivided hemispheres as a bridge to cross the interhemispheric fissure.