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"Intrinsic" heart rate in diabetic neuropathy
International Journal of Clinical Pharmacology and Biopharmacy
|July 1, 1977
Summary
Diabetic neuropathy patients exhibit higher resting heart rates. Autonomic blockade with atropine and propranolol did not further increase heart rate in these patients compared to controls or non-neuropathic diabetics.
Area of Science:
- Cardiology
- Neurology
- Endocrinology
Background:
- Diabetic neuropathy affects autonomic control of the heart.
- Understanding heart rate changes is crucial for managing diabetic complications.
Purpose of the Study:
- To investigate heart rate dynamics in diabetic neuropathy.
- To assess the impact of autonomic innervation blockade on heart rate.
Main Methods:
- Studied heart frequency changes in patients with diabetic neuropathy.
- Administered atropine and propranolol to block autonomic innervation.
- Compared heart rates to control groups and non-neuropathic diabetics.
Main Results:
- Patients with diabetic neuropathy had a higher initial heart rate.
- Autonomic blockade did not lead to a further significant increase in heart rate.
- Heart rate response to autonomic blockade differed in neuropathic versus non-neuropathic diabetics.
Conclusions:
- Diabetic neuropathy is associated with altered intrinsic heart rate.
- The autonomic nervous system's role in heart rate regulation may be impaired in diabetic neuropathy.