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Related Experiment Videos

Autoregulation during pressor response elevates wall shear rate in arterioles

D T Kurjiaka1, S S Segal

  • 1The John B. Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 1, 1996
PubMed
Summary

Autoregulation of muscle blood flow during increased blood pressure involves arteriolar constriction, maintaining blood flow in smaller vessels. This process increases wall shear rate (WSR) in arterioles, ensuring stable flow despite pressure changes.

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Area of Science:

  • Physiology
  • Cardiovascular System
  • Microcirculation

Background:

  • Autoregulation is crucial for maintaining stable organ blood flow despite fluctuations in perfusion pressure.
  • Understanding the mechanisms of blood flow autoregulation in microvascular networks is essential for cardiovascular research.

Purpose of the Study:

  • To investigate blood flow autoregulation in arteriolar networks during a pressor response.
  • To determine if wall shear rate (WSR) increases during autoregulation in response to altered perfusion pressure.

Main Methods:

  • Intravital videomicroscopy was used to monitor arteriolar diameter and red blood cell velocity (VRBC) in male hamsters.
  • Measurements were taken at rest and during a pressor response induced by bilateral carotid artery occlusion (CAO).

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  • Calculations included wall shear rate (WSR) and blood flow in different arteriolar orders (1A-4A).

    • Main Results:

    • During CAO-induced pressor response, arterial pressure increased significantly.
    • While 1A arterioles dilated, 2A-4A arterioles constricted, indicating autoregulation.
    • Red blood cell velocity (VRBC) and WSR increased in all measured arterioles.
    • Blood flow increased in 1A and 2A arterioles but remained autoregulated (unchanged) in 3A and 4A arterioles.

    Conclusions:

    • Autoregulation of muscle blood flow during a pressor response is achieved through myogenic constriction of arterioles.
    • This constriction leads to a concomitant elevation of wall shear rate (WSR) in the microvasculature.
    • Alpha-adrenoceptor blockade did not affect the observed arteriolar constrictions.