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Altitude and beta-blockade augment glucose utilization during submaximal exercise

A C Roberts1, J T Reeves, G E Butterfield

  • 1University of California, Berkeley 94720, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 1, 1996
PubMed
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Altitude exposure increases glucose utilization during rest and exercise, with beta-blockade further enhancing this effect. This study investigated glucose metabolism changes at high altitudes and the role of beta-adrenergic mechanisms.

Area of Science:

  • Human Physiology
  • Metabolic Research
  • Altitude Medicine

Background:

  • Altitude exposure significantly impacts physiological processes, including energy metabolism.
  • Beta-adrenergic pathways play a crucial role in regulating glucose homeostasis.
  • Understanding glucose utilization at altitude is vital for optimizing performance and health.

Purpose of the Study:

  • To investigate the effects of acute and chronic altitude exposure on glucose metabolism during rest and exercise.
  • To determine if beta-adrenergic blockade influences glucose utilization at altitude.
  • To elucidate the mechanisms underlying altitude-induced changes in glucose kinetics.

Main Methods:

  • Healthy male subjects (beta-blocked and control groups) underwent studies at sea level, acute altitude (4,300 m), and after acclimatization.

Related Experiment Videos

  • Glucose rates of appearance (Ra), disappearance (Rd), oxidation (Rox), and leg uptake (G) were measured using stable isotope tracers ([6,6-2H]- and [1-13C]glucose).
  • Measurements were taken during rest and a standardized submaximal exercise protocol (89 W).

    • Main Results:

    • Altitude exposure significantly increased glucose Ra and Rox during rest and exercise compared to sea level.
    • Beta-blockade augmented glucose Ra and Rox at both sea level and altitude.
    • Glucose uptake by the legs (G) increased substantially during exercise at altitude, particularly in beta-blocked individuals.
    • Acclimatization reduced, but did not eliminate, the altitude-induced increases in glucose Ra, Rox, and G during exercise.

    Conclusions:

    • Altitude exposure enhances glucose utilization during rest and submaximal exercise.
    • Beta-adrenergic mechanisms significantly contribute to the regulation of glucose metabolism at altitude.
    • Beta-blockade potentiates altitude-induced increases in glucose utilization and oxidation.
    • These findings have implications for understanding metabolic adaptations to high-altitude environments.