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Imipramine-induced increase in 5-HT2C receptor mRNA level in the rat brain
1Division of Pharmacology, Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University, Japan.
Neuroscience Research
|January 1, 1996
Abstract:
Repeated oral administration of 20 mg/kg imipramine elevated the level of 5-HT2C mRNA in the rat brain. Hybridization signals in nearly all regions stained by digoxigenin-labeled antisense cRNA probe, such as the hippocampus, choroid plexus, habenular nucleus, and dorsomedial hypothalamic nucleus, were more intense following imipramine treatment. These results suggest that long-term treatment with imipramine stimulates 5-HT2C receptor gene expression.