Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Oct-2 transcription factor

D S Latchman1

  • 1Department of Molecular Pathology, University College London Medical School, U.K.

The International Journal of Biochemistry & Cell Biology
|October 1, 1996
PubMed
Summary

Oct-2, a POU family transcription factor, regulates gene expression in B lymphocytes and neurons. Alternative splicing creates variants with activating or repressing functions, impacting cellular and viral gene activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells.

Oncogene·2023
Same author

STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy.

Journal of cellular and molecular medicine·2011
Same author

Herpes simplex virus life cycle and the design of viral vectors.

Methods in molecular biology (Clifton, N.J.)·2011
Same author

Growth of herpes simplex virus and purification of viral DNA.

Methods in molecular biology (Clifton, N.J.)·2011
Same author

HSV-Cellular Protein Interactions.

Methods in molecular medicine·2011
Same author

EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A.

Oncogene·2010

Area of Science:

  • Molecular Biology
  • Immunology
  • Neuroscience

Background:

  • Oct-2 is a transcription factor from the POU family.
  • It is specifically expressed in B lymphocytes and neuronal cells.
  • Oct-2 regulates gene expression through alternative splicing.

Purpose of the Study:

  • To investigate the dual role of Oct-2 in gene regulation.
  • To understand the differential functions of Oct-2 variants in B cells and neurons.
  • To explore Oct-2's involvement in viral latency.

Main Methods:

  • Analysis of Oct-2 gene expression patterns.
  • Studying alternative splicing of Oct-2 transcripts.
  • Assessing the impact of Oct-2 variants on gene expression in B cells and neuronal cells.

Main Results:

  • Oct-2 variants in B cells predominantly activate gene expression.
  • Oct-2 variants in neuronal cells predominantly repress gene expression.
  • Neuronal Oct-2 represses herpes simplex virus immediate-early genes and tyrosine hydroxylase gene.

Conclusions:

  • Oct-2 plays a critical role in regulating cellular gene expression in both B cells and neurons.
  • Differential splicing of Oct-2 contributes to cell-specific functions.
  • Oct-2 is involved in controlling viral latency, particularly in neuronal cells.

Related Experiment Videos