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Contact allergy to the active ingredients of Bioban P 1487
B Gruvberger1, M Bruze, E Zimerson
1Department of Occupational and Environmental Dermatology, University Hospital, Malmö, Sweden.
Abstract:
Bioban P 1487, consisting of the 2 active ingredients 4-(2-nitrobutyl)-morpholine (M) and 4,4'-(2-ethyl-2-nitro-1,3-propanediyl)-bis morpholine (DM), is a preservative recommended for mental working fluids. The aims of this study were to assess the frequency of contact allergy to Bioban P 1487, when added to a standard patch test series, as well as to test the individual active ingredients in patients sensitized to Bioban P 1487. Of the patients consecutively tested, 1.5% reacted positively to Bioban P 1487. Positive test reactions were noted in only 4 of 12 Bioban P 1487-sensitized patients tested with the individual active ingredients. Both active ingredients are contact sensitizers, but in most patients with this contact allergy it remains difficult to identify the sensitizing hapten.
Insights
Bioban P 1487, a preservative in metalworking fluids, caused allergic contact dermatitis in 1.5% of patients tested. Identifying the specific sensitizing ingredient proved challenging for most affected individuals.
Area of Science:
- Dermatology
- Occupational Health
- Toxicology
Background:
- Bioban P 1487 is a preservative used in metalworking fluids.
- It contains two active ingredients: 4-(2-nitrobutyl)-morpholine (M) and 4,4'-(2-ethyl-2-nitro-1,3-propanediyl)-bis morpholine (DM).
- Contact allergy to preservatives is a concern in occupational settings.
Purpose of the Study:
- To determine the frequency of contact allergy to Bioban P 1487.
- To evaluate the sensitizing potential of its individual active ingredients.
- To identify the specific causative agent in patients with Bioban P 1487 allergy.
Main Methods:
- A standard patch test series was employed.
- Patients were tested with Bioban P 1487.
- Patients sensitized to Bioban P 1487 were further tested with its individual active ingredients (M and DM).
Main Results:
- 1.5% of consecutively tested patients showed a positive reaction to Bioban P 1487.
- Only 4 out of 12 Bioban P 1487-sensitized patients reacted to the individual active ingredients.
- Both M and DM were identified as contact sensitizers.
Conclusions:
- Bioban P 1487 can cause allergic contact dermatitis.
- While both active ingredients are sensitizers, pinpointing the exact cause in sensitized individuals is often difficult.
- Further investigation may be needed to clarify sensitization patterns.