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CD15-containing glycoconjugates in the central nervous system
A Gocht1, G Struckhoff, J Lhler
1Institut für Pathologie, Marienkrankenhaus, Hamburg, Germany.
Histology and Histopathology
|October 1, 1996
Summary
CD15, a carbohydrate epitope, is found in the brain and other tissues. Its expression changes during development and in disease, potentially influencing cell behavior and interactions.
Area of Science:
- Neuroscience
- Glycobiology
- Cell Biology
Background:
- CD15 is a trisaccharide epitope (3-fucosyl-N-acetyllactosamine) recognized by monoclonal antibodies.
- CD15 is widely distributed in epithelial tissues and the central nervous system (CNS).
Purpose of the Study:
- To investigate the distribution and potential roles of CD15 in the mammalian brain.
- To explore the expression patterns of CD15 during neural development and in CNS lesions.
Main Methods:
- Immunohistochemical studies were employed to detect CD15 distribution.
- Expression patterns were analyzed during glial and neuronal development and in various CNS conditions.
Main Results:
- CD15 is consistently present in astrocytes and variably in oligodendrocytes and neurons in the mature brain.
- CD15 expression follows specific temporal patterns during development in regions like the cerebellum and visual system.
- Altered CD15 expression is observed in CNS lesions, including gliomas and degenerative diseases, with inverse correlation to glioma malignancy.
- Reactive astrocytes in degenerative diseases show increased CD15 labeling and abnormal cytosolic accumulation.
Conclusions:
- CD15 expression in the CNS is dynamic, varying with cell type, developmental stage, and disease state.
- CD15 may play roles in cell migration during development (growth-promoting or repulsive) and in cellular adhesion or signal transduction in the adult CNS.
- Further research is needed to elucidate the precise functional significance of CD15 in the CNS.