Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparing methods for calculating confidence intervals for vaccine efficacy

M Ewell1

  • 1EMMES Corporation, Potomac, Maryland 20854, USA.

Statistics in Medicine
|November 15, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Economic analysis of unrelated allogeneic bone marrow transplantation: results from the randomized clinical trial of T-cell depletion vs unmanipulated grafts for the prevention of graft-versus-host disease.

Bone marrow transplantation·2005
Same author

Examination of peak power dependence in the UV inactivation of bacterial spores.

Applied and environmental microbiology·2001
Same author

Prednisone withdrawal in kidney transplant recipients on cyclosporine and mycophenolate mofetil--a prospective randomized study. Steroid Withdrawal Study Group.

Transplantation·2000
Same author

Inference using conditional logistic regression with missing covariates.

Biometrics·1998
Same author

Risk factors associated with preeclampsia in healthy nulliparous women. The Calcium for Preeclampsia Prevention (CPEP) Study Group.

American journal of obstetrics and gynecology·1997
Same author

The large sample distribution of the weighted log rank statistic under general local alternatives.

Lifetime data analysis·1997
Same journal

Predictor-Assisted Nonparametric Graphical Models With Multivariate Error-Prone Data.

Statistics in medicine·2026
Same journal

Optimizing Treatment Decision Estimation for Right-Censored Survival Data Through Parameter Transfer Learning.

Statistics in medicine·2026
Same journal

Latent Class Log-Linear Models for Estimating Diagnostic Test Accuracy Without a Gold Standard: A Simulation Study.

Statistics in medicine·2026
Same journal

Interpretable Bayesian Modeling for Multireader Multicase Studies: Addressing Overdispersion and Limited Sample Size in Diagnostic Enhancement Evaluation.

Statistics in medicine·2026
Same journal

Adaptive Sequential Multiple Hypotheses Testing for Concomitant Vaccine Safety Surveillance.

Statistics in medicine·2026
Same journal

Novel Distance Regression for Repeated Outcomes With Missing Data: Applications to Longitudinal and Crossover Studies of Microbiome Beta-Diversity.

Statistics in medicine·2026
See all related articles

This study introduces a Bayesian method for vaccine efficacy calculation, comparing its results with frequentist approaches. The Bayesian method with vague priors provides comparable outcomes to traditional frequentist confidence intervals for vaccine efficacy.

Area of Science:

  • Biostatistics
  • Clinical Trials
  • Vaccinology

Background:

  • Evaluating vaccine efficacy is crucial for public health interventions.
  • Frequentist methods are standard for constructing confidence intervals for vaccine efficacy.
  • Bayesian approaches offer an alternative framework for statistical inference in clinical trials.

Purpose of the Study:

  • To introduce a Bayesian method for calculating the 95% posterior probability region for vaccine efficacy.
  • To compare the results of this Bayesian approach with vague prior information to traditional frequentist methods.
  • To assess the performance of Bayesian and frequentist methods in randomized controlled trials.

Main Methods:

  • A Bayesian method using independent vague gamma prior distributions for incidence rates and a Poisson likelihood for infection counts.

Related Experiment Videos

  • Comparison with exact and large-sample frequentist confidence interval methods for vaccine efficacy.
  • Assessment of statistical power and interval size for both Bayesian and frequentist approaches.

    • Main Results:

    • The Bayesian approach with vague priors yields results comparable to frequentist methods for vaccine efficacy estimation.
    • The study provides a framework for comparing Bayesian and frequentist interval construction methods.
    • Evaluation of interval size and power demonstrates the comparability of the two statistical paradigms.

    Conclusions:

    • The Bayesian method with vague priors is a viable alternative to frequentist approaches for vaccine efficacy assessment.
    • Both Bayesian and frequentist methods provide comparable results in the context of vaccine efficacy trials.
    • This research supports the use of Bayesian statistics in clinical trial analysis for vaccine efficacy.