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Synthesis and biological activity of a conformationally constrained chemotactic gamma-lactam formyl tetrapeptide
G Cavicchioni1, A Breveglieri, E Reali
1Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.
Arzneimittel-Forschung
|October 1, 1996
Abstract:
The synthesis and biological activity on human neutrophils of for-Met-(gamma-lactam)-Leu-Phe-OMe [fM(gamma l)LP-OMe], an analogue of the chemotactic fMLP-OMe, are reported. The tetrapeptide evidences chemotactic activity as well as superoxide anion production and lysozyme release, although with lower efficacy when compared with the parent tripeptide.