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The menopausal transition

H G Burger1

  • 1Prince Henry's Institute of Medical Research, Victoria, Australia.

Bailliere'S Clinical Obstetrics and Gynaecology
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

The menopausal transition involves declining ovarian follicles and rising FSH levels. Women may experience increased symptoms and risks for cardiovascular disease and osteoporosis during this phase.

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Area of Science:

  • Reproductive endocrinology
  • Gynecology
  • Women's health

Background:

  • The menopausal transition is defined by hormonal shifts and ovarian changes.
  • Follicular atresia accelerates, leading to a reduced number of primordial follicles.
  • Hormonal fluctuations, particularly elevated Follicle-Stimulating Hormone (FSH), characterize this period.

Purpose of the Study:

  • To describe the key physiological and hormonal changes during the menopausal transition.
  • To highlight the increased reporting of symptoms during this life stage.
  • To inform medical practitioners about potential health risks and interventions.

Main Methods:

  • Observational study of hormonal profiles (FSH, oestradiol, inhibin) during the menopausal transition.
  • Analysis of ovarian follicular dynamics.

Related Experiment Videos

  • Correlation of symptom reporting with menopausal stage.

    • Main Results:

    • A progressive rise in serum FSH levels is the most consistent hormonal change.
    • Oestradiol and inhibin levels fluctuate but are preserved in early stages.
    • Anovulatory cycles increase, and symptom frequency peaks during the menopausal transition.

    Conclusions:

    • The menopausal transition is marked by declining ovarian reserve and hormonal shifts.
    • Increased symptom reporting and potential adverse changes in cardiovascular and osteoporosis risk factors are noted.
    • Hormonal supplementation should be considered for women at higher risk of cardiovascular disease and osteoporotic fractures.