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Treatments for menopausal and post-menopausal problems: present and future

M Whitehead1

  • 1Menopause Clinic, Kings College School of Medicine & Dentistry, London, UK.

Bailliere'S Clinical Obstetrics and Gynaecology
|September 1, 1996
PubMed
Summary

Developments in hormone replacement therapy (HRT) and non-HRT treatments for menopausal symptoms are reviewed. Further research is needed on HRT benefits like stroke prevention and side effects such as ovarian cancer.

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Area of Science:

  • Reproductive endocrinology and women's health.

Background:

  • Menopause and post-menopausal issues require effective treatment strategies.
  • Hormone replacement therapy (HRT) and non-HRT alternatives are evolving.
  • Understanding the risks and benefits of current and future treatments is crucial.

Purpose of the Study:

  • To review probable developments in HRT and non-HRT treatments for menopausal and post-menopausal problems.
  • To highlight the need for more data on HRT's benefits and side effects.
  • To discuss emerging therapies and their potential impact.

Main Methods:

  • Literature review of probable developments in menopausal treatments.
  • Analysis of potential benefits and side-effects of HRT.
  • Evaluation of current and future delivery systems for hormonal therapies.

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  • Assessment of preliminary data on SERMs and phytoestrogens.

    • Main Results:

    • HRT's major potential benefits include stroke prevention and Alzheimer's disease amelioration.
    • Ovarian cancer is identified as a major potential side-effect of HRT.
    • Oestrogen delivery systems are more advanced than progestogen systems.
    • Non-oral progestogen delivery systems are expected within a decade.
    • The benefits of new progestational agents require further validation.
    • Selective estrogen receptor modulators (SERMs) and phytoestrogens show promise.

    Conclusions:

    • Further research is essential to clarify HRT's benefits and risks.
    • Advancements in progestogen delivery aim to minimize side-effects.
    • SERMs and phytoestrogens warrant further investigation for menopausal symptom management.
    • The next decade is expected to bring significant advancements and interest in these treatments.