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Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling
M Givskov1, R de Nys, M Manefield
1Department of Microbiology, The Technical University of Denmark, Lyngby.
Journal of Bacteriology
|November 1, 1996
Abstract:
Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.