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Genes and obesity

L B Andersson

    Annals of Medicine
    |February 1, 1996
    PubMed
    Summary
    This summary is machine-generated.

    Obesity has a strong genetic basis, influenced by multiple genes and environment. Research identified the ob gene (leptin) and its receptor, crucial for regulating food intake and body weight.

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    Area of Science:

    • Genetics
    • Obesity Research
    • Animal Models

    Background:

    • Obesity is a complex trait with significant genetic underpinnings, supported by twin, adoption, and animal studies.
    • While polygenic inheritance is common, specific genes can play major roles within families, though these may differ across families.
    • Mouse models identified the ob and db genes, likely encoding a satiety hormone and its receptor, respectively, influencing food intake.