Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated soluble CD23 levels in the sera from patients with localized scleroderma

S Sato1, M Fujimoto, K Kikuchi

  • 1Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.

Archives of Dermatological Research
|February 1, 1996
PubMed
Summary

Elevated soluble CD23 (sCD23) levels indicate B-cell activation in localized scleroderma. Higher sCD23 correlates with autoantibodies and disease severity, suggesting its potential as a new serological marker.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Absence of microsatellite instability in extramammary Paget's disease.

Skin health and disease·2022
Same author

Genomic mutational profiling of circulating tumour DNA in metastatic angiosarcoma.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Retrospective study of COL1A1-PDGFB fusion gene-positive dermatofibrosarcoma protuberans in Kumamoto University.

Clinical and experimental dermatology·2020
Same author

The Warburg effect and tumour immune microenvironment in extramammary Paget's disease: overexpression of lactate dehydrogenase A correlates with immune resistance.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Serum cell-free DNA levels are a useful marker for extramammary Paget disease.

The British journal of dermatology·2019
Same author

Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway.

The British journal of dermatology·2017

Area of Science:

  • Immunology
  • Dermatology
  • Autoimmune Diseases

Background:

  • Soluble CD23 (sCD23) is linked to B-cell activation.
  • Elevated sCD23 serum levels are observed in various autoimmune disorders.
  • Localized scleroderma is a condition with potential immunologic involvement.

Purpose of the Study:

  • To investigate serum sCD23 levels in localized scleroderma.
  • To correlate sCD23 levels with immunologic abnormalities and clinical features.
  • To assess sCD23 as a potential biomarker for localized scleroderma severity.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure serum sCD23.
  • 49 serum samples were analyzed from patients with generalized morphoea, linear scleroderma, and morphoea.

Related Experiment Videos

  • Comparison was made between patient subgroups and healthy individuals.

    • Main Results:

    • Serum sCD23 levels were significantly higher in localized scleroderma patients versus healthy controls.
    • Generalized morphoea subgroup showed the highest sCD23 levels.
    • Elevated sCD23 correlated with increased IgM antihistone antibody, IgM rheumatoid factor, linear lesions, and muscle involvement.

    Conclusions:

    • Elevated sCD23 reflects B-cell activation in localized scleroderma.
    • sCD23 levels correlate with IgM autoantibody production and disease severity.
    • Serum sCD23 may serve as a novel serological indicator for localized scleroderma severity.