Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral blood stem cells for allogeneic transplantation

I Majolino1, A M Cavallaro, R Scimè

  • 1Department of Hematology and Bone Marrow Transplant Unit, Ospedale Cervello, Palermo, Italy.

Bone Marrow Transplantation
|November 1, 1996
PubMed
Summary

Allogeneic peripheral blood stem cell transplantation (PBSCT) is now standard practice. While PBSCT offers rapid engraftment and potential graft-versus-leukemia effects, survival outcomes are comparable to bone marrow transplantation (BMT).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The capacity-building approach was successful in the start-up process of the first HSCT center in Iraqi Kurdistan.

Bone marrow transplantation·2017
Same author

Autologous stem cell transplantation is still a valid option in good- and intermediate-risk AML: a GITMO survey on 809 patients autografted in first complete remission.

Bone marrow transplantation·2016
Same author

The Role of Allogeneic Transplantation in the Treatment of Multiple Myeloma.

Hematology (Amsterdam, Netherlands)·2016
Same author

Thiotepa-based high-dose therapy for autologous stem cell transplantation in lymphoma: a retrospective study from the EBMT.

Bone marrow transplantation·2015
Same author

Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy.

Bone marrow transplantation·2014
Same author

Results of a randomized trial comparing high-dose chemotherapy plus Auto-SCT and R-FC in CLL at diagnosis.

Bone marrow transplantation·2014

Area of Science:

  • Hematology
  • Transplantation Immunology
  • Oncology

Background:

  • Peripheral blood stem cell transplantation (PBSCT) is increasingly utilized, moving beyond experimental status.
  • G-CSF mobilization is standard for PBSC collection, with generally acceptable side effects, though thrombocytopenia can occur.
  • Allogeneic PBSC demonstrate faster engraftment kinetics compared to bone marrow (BM) for both platelets and granulocytes.

Purpose of the Study:

  • To evaluate the efficacy and safety of allogeneic PBSCT compared to traditional bone marrow transplantation (BMT).
  • To assess graft-versus-host disease (GVHD) incidence and graft stability in PBSCT.
  • To explore the potential benefits of T- and NK-cells infused with PBSC.

Main Methods:

  • Review of existing data on PBSC collection, engraftment, graft stability, and GVHD incidence.

Related Experiment Videos

  • Comparison of PBSCT outcomes with historical BMT data.
  • Discussion of T-cell depletion strategies and CD34+ cell selection in PBSCT.

    • Main Results:

    • PBSCT shows rapid engraftment and documented graft stability via DNA analysis.
    • Acute GVHD incidence in PBSCT is similar to BMT, but chronic GVHD data are conflicting.
    • Infusion of T- and NK-cells in PBSC may enhance graft-versus-leukemia (GVL) effect, though evidence is primarily from murine models.
    • Current data suggest PBSCT survival outcomes are not inferior to BMT.

    Conclusions:

    • Allogeneic PBSCT is a viable alternative to BMT, offering comparable survival rates.
    • Further prospective studies are needed to definitively establish the superiority of PBSCT over BMT.
    • Strategies for optimizing PBSCT, including T-cell modulation, require continued investigation.