Staining of the nucleolar organizer regions: relevance in hematology

There is growing interest in staining for the nucleolar organizer regions to detect nucleolar organizer region-associated proteins. In some cases, this technique facilitates the study of hematological disorders and allows us to distinguish between certain pathologies. Furthermore, it can provide information about cell proliferation, activity and malignancy. This paper attempts to give the recent advances in the use of the staining of nucleolar organizer regions and its clinical relevance in hematology.