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Quinidine administration increases steady state serum digoxin concentration in horses
M E Parraga1, M D Kittleson, C M Drake
1Veterinary Medical Teaching Hospital, University of California, Davis, USA.
Equine Veterinary Journal. Supplement
|September 1, 1995
Summary
Quinidine administration significantly increases serum digoxin concentration in horses, nearly doubling levels. This interaction is partly due to reduced renal digoxin clearance, a finding with implications for equine pharmacotherapy.
Area of Science:
- Veterinary Pharmacology
- Equine Medicine
- Drug Interactions
Background:
- Digoxin is a cardiac glycoside used in horses.
- Quinidine is an antiarrhythmic drug.
- Potential drug interactions between digoxin and quinidine require investigation in horses.
Purpose of the Study:
- To determine if quinidine affects steady-state serum digoxin concentrations in horses.
- To investigate the impact of quinidine on digoxin pharmacokinetics, specifically renal clearance.
Main Methods:
- Horses received daily oral digoxin to reach steady state.
- Serum digoxin concentrations were measured before and after quinidine administration.
- Renal digoxin and creatinine clearances were assessed.
Main Results:
- Quinidine administration approximately doubled steady-state serum digoxin concentrations.
- This increase persisted for 12 hours post-administration.
- Renal digoxin clearance decreased significantly, partly due to reduced glomerular filtration.
Conclusions:
- Quinidine increases serum digoxin concentration in horses, similar to other species.
- Reduced renal digoxin clearance is a primary mechanism for this interaction in horses.
- The contribution of decreased glomerular filtration differs from findings in other species.