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Structure-activity relationships of some 1,4-benzodioxane aryl-piperazine derivatives as alpha-blocking agents
S Corsano1, G Strappaghetti, R Scapicchi
1Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy.
Archiv Der Pharmazie
|October 1, 1996
Abstract:
The synthesis of eight novel 1,4-benzodioxane derivatives is reported. The blocking activity of these compounds was determined on the pre- and postsynaptic alpha-adrenoceptors of isolated rat vas deferens. Structure-activity relationships are discussed.