Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective broad-band spatial frequency loss in contrast sensitivity functions. Comparison with a model based on

L J Bour1, P Apkarian

  • 1Department of Neurology, Academic Medical Centre, University of Amsterdam, The Netherlands.

Investigative Ophthalmology & Visual Science
|November 1, 1996
PubMed
Summary

Slight refractive errors can cause broad contrast sensitivity loss, mimicking vision loss from various eye diseases. Optical factors must be considered before attributing vision deficits to neural issues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Closing the loop: Novel quantitative fMRI approach for manipulation of the sensorimotor loop in tremor.

NeuroImage·2022
Same author

Directionality of corticomuscular coupling in essential tremor and cortical myoclonic tremor.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021
Same author

Eye movement abnormalities in essential tremor versus tremor dominant Parkinson's disease.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2019
Same author

Cerebral dopamine deficiency, plasma monoamine alterations and neurocognitive deficits in adults with phenylketonuria.

Psychological medicine·2017
Same author

Directional Recording of Subthalamic Spectral Power Densities in Parkinson's Disease and the Effect of Steering Deep Brain Stimulation.

Brain stimulation·2015
Same author

Tic related local field potentials in the thalamus and the effect of deep brain stimulation in Tourette syndrome: Report of three cases.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2014

Area of Science:

  • Ophthalmology
  • Vision Science
  • Optical Physics

Background:

  • Contrast sensitivity is crucial for visual function.
  • Understanding factors affecting contrast sensitivity is important for diagnosing visual impairments.

Purpose of the Study:

  • To measure contrast sensitivity functions (CSFs) under various optical conditions in healthy individuals and patients.
  • To compare experimental CSFs with predictions from a theoretical optical model.

Main Methods:

  • Determined contrast thresholds across spatial frequencies using a computer-automated method.
  • Simulated contrast sensitivity losses in healthy subjects by manipulating pupil diameter and dioptric blur.
  • Calculated modulation transfer functions incorporating various optical aberrations.

Related Experiment Videos

Main Results:

  • Slight dioptric blur increased CSF thresholds, causing broad sensitivity loss across spatial frequencies.
  • Optically induced CSF losses in healthy subjects were indistinguishable from those in patients with visual pathway diseases.
  • Patient CSFs were not specific to their underlying pathologic condition.

Conclusions:

  • Broad-band contrast sensitivity loss can be induced by optical factors like refractive error.
  • Neural factors cannot be assumed for contrast sensitivity loss in patients without accounting for optical variables.