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Related Experiment Videos

Technique for measuring hippocampal T2 relaxation time

J S Duncan1, P Bartlett, G J Barker

  • 1MR Unit, National Society for Epilepsy, Institute of Neurology, Bucks, United Kingdom.

AJNR. American Journal of Neuroradiology
|November 1, 1996
PubMed
Summary

Conventional spin-echo (CSE) T2 mapping provides reliable hippocampal T2 values for assessing brain structures like the hippocampus. This method offers accurate and reproducible measurements for clinical applications.

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Area of Science:

  • Neuroimaging
  • Magnetic Resonance Imaging (MRI)
  • Quantitative MRI

Background:

  • Accurate T2 mapping of the hippocampus is crucial for diagnosing neurological conditions.
  • Existing methods may have limitations in reliability or coverage.
  • Developing robust T2 mapping techniques is essential for quantitative brain analysis.

Purpose of the Study:

  • To implement and validate methods for calculating coronal T2 maps.
  • To ensure complete coverage of the hippocampus and the entire brain.
  • To assess the reliability and utility of T2 mapping for cerebral structures.

Main Methods:

  • T2 relaxation times were measured using fast spin-echo (FSE) and conventional spin-echo (CSE) sequences.
  • Hippocampal T2 relaxation times were assessed in healthy subjects and patients with temporal lobe epilepsy.

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  • Test-retest and interrater reliability of CSE sequences were evaluated.

    • Main Results:

    • Conventional spin-echo (CSE) sequences demonstrated higher reliability than FSE sequences.
    • The CSE sequence with echo time 30,120 showed superior reliability for hippocampal T2 measures.
    • CSE T2 mapping correlated well with a validated multiecho technique and identified hippocampal sclerosis.

    Conclusions:

    • T2 mapping using CSE 30/120 sequences is readily applicable and reliable.
    • This method provides contiguous 5-mm sections for T2 value assessment.
    • CSE T2 mapping is potentially useful for evaluating the hippocampus and other brain structures.