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Related Experiment Videos

Cutaneous reaction to naproxen

M A Gonzalo Garijo1, P Bobadilla González

  • 1Allergology Department, Infanta Cristina University Hospital, Badajoz, Spain.

Allergologia Et Immunopathologia
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

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Fixed drug eruption (FDE) is a rare reaction to naproxen, often linked to menstruation. Oral challenge confirmed naproxen as the cause in a patient with recurrent, pigmented skin lesions.

Area of Science:

  • Dermatology
  • Clinical Pharmacology

Background:

  • Fixed drug eruption (FDE) is a rare adverse drug reaction characterized by recurrent lesions at the same site upon re-exposure to a causative agent.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are common triggers for FDE, but naproxen-induced FDE is exceptionally rare.

Observation:

  • A 28-year-old woman presented with a 2-year history of recurrent, itchy, erythematous plaques and blisters on her face and neck, associated with menstruation and naproxen sodium use.
  • Lesions resolved within 1-2 weeks, leaving hyperpigmentation. Oral mucosal involvement and recurrence in the same locations were noted.
  • Patch testing with NSAIDs was negative on normal skin. However, application to previous FDE sites resulted in hyperpigmentation, with unclear diagnostic value.

Findings:

  • An oral challenge test with naproxen definitively confirmed naproxen as the causative agent for the fixed drug eruption.

Related Experiment Videos

  • The diagnostic challenge of FDE is highlighted, particularly when standard patch testing yields equivocal results.

    • Implications:

    • This case underscores the importance of considering FDE in patients with recurrent, site-specific cutaneous reactions, even with rare triggers like naproxen.
    • The diagnostic utility of oral challenge tests in FDE is reinforced, especially when patch tests are inconclusive.
    • Clinicians should be aware of the potential for naproxen to cause FDE, particularly in women experiencing dysmenorrhea-related drug use.