Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vancomycin-induced Stevens-Johnson syndrome

I I Alexander1, P A Greenberger

  • 1Department of Medicine, Northwestern University Medical School, Chicago, IL 60611-3008, USA.

Allergy and Asthma Proceedings
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International Consensus on drug allergy.

Allergy·2014
Same author

Molecular characterization of aspergillus fumigatus allergens.

The Indian journal of chest diseases & allied sciences·2004
Same author

Clinical, pathologic, and toxicologic findings in asthma deaths in Cook County, Illinois.

Allergy and asthma proceedings·2001
Same author

Problems in the management of idiopathic anaphylaxis.

Allergy and asthma proceedings·2001
Same author

T cell proliferation and cytokine secretion to T cell epitopes of Asp f 2 in ABPA patients.

Clinical immunology (Orlando, Fla.)·2001
Same author

Cloning and expression of Aspergillus fumigatus allergen Asp f 16 mediating both humoral and cell-mediated immunity in allergic bronchopulmonary aspergillosis (ABPA).

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2001

A rare Stevens-Johnson syndrome case occurred in a healthy patient due to vancomycin. This reaction involved skin, lymph nodes, liver, and blood abnormalities, responding to corticosteroids.

Area of Science:

  • Immunology
  • Dermatology
  • Pharmacology

Background:

  • Stevens-Johnson syndrome is a severe, rare immunologic drug reaction.
  • Vancomycin is an antibiotic with potential for serious adverse effects.
  • Drug-induced hypersensitivity reactions can manifest with diverse clinical presentations.

Observation:

  • A 36-year-old male developed a widespread rash, fever, neutropenia, and eosinophilia on vancomycin.
  • The patient later experienced lymphadenopathy, hepatitis, and serologic abnormalities.
  • Symptoms improved rapidly after discontinuing vancomycin and initiating corticosteroid therapy.

Findings:

  • This case presents vancomycin-induced Stevens-Johnson syndrome in a previously healthy individual.
  • The reaction was complicated by lymphadenopathy, hepatitis, and multiple serologic abnormalities.

Related Experiment Videos

  • This is the first reported instance of these complications in a healthy patient with vancomycin-induced Stevens-Johnson syndrome.

    • Implications:

    • Highlights the potential for severe, multi-systemic reactions to vancomycin, even in healthy patients.
    • Suggests the importance of vigilant monitoring for Stevens-Johnson syndrome and related complications during vancomycin therapy.
    • Corticosteroids may be effective in managing severe vancomycin-induced hypersensitivity reactions.