Practical use of rectal medications in palliative care

The rectal route of drug administration is an efficient and economical method for pharmacologic intervention in the terminally ill patient for whom the oral route is precluded. This review first describes the physiology and general considerations surrounding rectal drug administration, then evaluates the literature pertaining to analgesic and adjuvant medications and dosage forms that are and are not approved for rectal administration by the U.S. Food and Drug Administration. A paucity of studies deal with rectal administration in terminally ill patients, and data have been gathered from pharmacokinetic studies or studies in which the drugs were used for other indications. Where plausible, practical clinical recommendations for the rectal use of opioids, nonopioid analgesics, anxiolytics, and other adjuvants are formulated.