Very high-dose streptomycin labyrinthectomy

Medical labyrinthectomy by systemic administration of streptomycin has proven safe and effective for treatment of selected patients with intractable vertigo. In most patients, 40 grams or less of streptomycin sulfate are required. However, otolaryngologists should be aware that much higher doses can be used safely in selected patients; and a small number of patients may be resistant to streptomycin toxicity even in doses over 100 grams.