Related Experiment Videos
Binding of [1-14C]methyl isocyanate to erythrocyte membrane proteins
B K Bhattacharya1, S K Sharma, D K Jaiswal
1Department of Biochemistry, Defence Research and Development Establishment, Gwalior, India.
Journal of Applied Toxicology : JAT
|March 1, 1996
Abstract:
We describe the interaction of methyl isocyanate with reactive sulphydryl groups of rat erythrocyte membrane proteins. Intraperitoneal administration, as well as in vitro incubation of methyl isocyanate, caused a significant reduction in the free sulphydryl content of erythrocyte membrane proteins. [1-14C]Methyl isocyanate was specifically bound to band III of the erythrocyte membrane and caused the breakdown of band III proteins.