Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Where am I? How a cell recognizes its positional information during morphogenesis

R I Hata1

  • 1Department of Tissue Physiology, Tokyo Medical and Dental University, Japan.

Cell Biology International
|January 1, 1996
PubMed
Summary

This review highlights extracellular matrix (ECM) and cell adhesion molecules as key "morphocreators" in biological development. It discusses their roles in morphogenesis, moving beyond traditional focus on morphogens and homeodomain proteins.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Induction of SPARC by VEGF in human vascular endothelial cells.

Biochemical and biophysical research communications·2001
Same author

Activin A induces expression of rat Sel-1l mRNA, a negative regulator of notch signaling, in rat salivary gland-derived epithelial cells.

Biochemical and biophysical research communications·2001
Same author

Transcriptional regulation of the human type I collagen alpha2 (COL1A2) gene by the combination of two dinucleotide repeats.

Gene·1999
Same author

Stimulation of collagen synthesis in rat cardiac fibroblasts by exposure to hypoxic culture conditions and suppression of the effect by natriuretic peptides.

Cell biology international·1997
Same author

Two-dimensional electrophoresis of the alpha-chains of collagens and its application to the determination of their isoelectric points.

Collagen and related research·1981
Same author

Glycosaminoglycan synthesis by liver parenchymal cell clones in culture and its change with transformation.

Biochimica et biophysica acta·1980

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Biochemistry

Background:

  • Morphogenesis, the biological process of shaping organisms, is extensively studied.
  • Existing research often focuses on signaling molecules like morphogens and homeodomain proteins for developmental planning.
  • The role of structural and adhesion molecules in actively creating form is less emphasized.

Purpose of the Study:

  • To review the function of extracellular matrix (ECM) and cell adhesion molecules in morphogenesis.
  • To present ECM and cell adhesion molecules as crucial
  • morphocreators
  • (form-creating molecules).
  • To discuss their significance as carriers of positional information during development.

Main Methods:

Related Experiment Videos

  • Literature review and synthesis of existing research on ECM and cell adhesion in morphogenesis.
  • Analysis of molecular mechanisms involving ECM and cell adhesion.
  • Discussion of experimental evidence supporting their roles.

    • Main Results:

    • ECM and cell adhesion molecules actively participate in shaping tissues and organs.
    • These molecules provide critical physical cues and structural support essential for morphogenesis.
    • They act as key determinants of cell position and fate within developing structures.

    Conclusions:

    • ECM and cell adhesion molecules are fundamental to morphogenesis, acting as direct agents of form creation.
    • Re-evaluating their role shifts focus from purely signaling molecules to include structural and interactive components.
    • Understanding these
    • morphocreators
    • is vital for a comprehensive view of developmental biology.