Triorganosilicon (IV) compounds: synthesis, structural study, and biological activity

Area of Science:

• Inorganic Chemistry
• Organosilicon Chemistry
• Medicinal Chemistry

Background:

• Silicon (IV) coordination chemistry is a developing field with potential applications.
• Organosilicon compounds offer diverse chemical properties and biological activities.
• Nitrogen-sulphur donor ligands are versatile in coordinating with metal centers.

Purpose of the Study:

• To synthesize novel silicon (IV) coordination compounds.
• To characterize the structure and properties of these new compounds.
• To evaluate the biological activity of the synthesized silicon compounds.

Main Methods:

• Synthesis of silicon (IV) compounds using trimethyl- and triphenyl-chlorosilane with N-S donor ligands.
• Characterization techniques including molecular weight determination, conductivity measurements, electronic, infrared (IR), and nuclear magnetic resonance (NMR) spectroscopy (1H and 13C).
• Biological activity assessment against various bacterial and fungal strains.

Main Results:

• Monomeric silicon (IV) coordination compounds were successfully synthesized.
• Compounds behaved as non-electrolytes in dry Dimethylformamide (DMF).
• Spectral data confirmed a penta-coordinated silicon center in a trigonal bipyramidal geometry.
• Significant antibacterial activity was observed against Proteus mirabilis and Streptococcus viridans.
• All synthesized compounds demonstrated potent fungicidal action against Fusarium oxysporum, Alternaria alternata, and Aspergillus niger.

Conclusions:

• The synthesized silicon (IV) compounds possess a trigonal bipyramidal structure.
• These compounds exhibit promising broad-spectrum antimicrobial properties.
• The findings suggest potential applications for these silicon coordination compounds in medicinal chemistry and agriculture.