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Hb Cook [beta 132(H10)Lys-->Thr]: a new hemoglobin variant in a southeast Asian family
P J Hutt1, V F Fairbanks, T C Griffin
1Department of Laboratory Medicine and Pathology Mayo Clinic, Rochester, MN 55905, USA.
Hemoglobin
|November 1, 1996
Abstract:
Approximately 700 hemoglobin variants have been reported, causing a variety of clinical manifestations, with the majority being clinically silent. We report a new hemoglobin variant, Hb Cook, that was found in combination with Hb E in a child of Thai origin. DNA sequencing of the beta-globin gene showed that the mutation is AAA-->ACA in codon 132, corresponding to beta 132 (H10)Lys-->Thr.