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Increased mean platelet volume after oestrogen replacement therapy

L R Ranganath1, J Christofides, M J Semple

  • 1Department of Clinical Biochemistry, Epsom Hospital Laboratories, Epsom General Hospital, Surrey, UK.

Annals of Clinical Biochemistry
|November 1, 1996
PubMed
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Hormone replacement therapy (HRT) in post-menopausal women increased mean platelet volume, suggesting heightened platelet reactivity. This study observed significant changes in platelet membrane fatty acids but no correlation with the increase in platelet size.

Area of Science:

  • Endocrinology
  • Hematology
  • Cardiovascular Research

Background:

  • Hormone replacement therapy (HRT) is used to manage menopausal symptoms.
  • The impact of HRT on platelet function and cardiovascular risk factors requires further investigation.

Purpose of the Study:

  • To investigate the effects of a specific HRT regimen on platelet indices and membrane fatty acid composition in post-menopausal women.

Main Methods:

  • 38 post-menopausal women received cyclical L-norgestrel and continuous conjugated equine oestrogens for 6 weeks.
  • Platelet indices (including mean platelet volume) were measured using Coulter analysis.
  • Platelet membrane fatty acids were analyzed via gas-liquid chromatography.

Main Results:

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  • HRT led to a significant reduction in platelet membrane linoleic acid, di-homo-gamma-linoleic acid, and arachidonic acid (p < 0.01).
  • A statistically significant increase in mean platelet volume (MPV) was observed (P < 0.05).
  • No significant correlation was found between changes in MPV and platelet membrane fatty acid alterations.

Conclusions:

  • The studied HRT regimen appears to increase mean platelet volume in post-menopausal women.
  • Increased MPV may suggest enhanced platelet reactivity, a potential factor in cardiovascular health.
  • Further research is needed to elucidate the clinical implications of these findings.