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Related Experiment Videos

Expression patterns of adhesion receptors in the developing mouse lung: functional implications

C A Buck1, J M Edelman, C E Buck

  • 1Wistar Institute, Philadelphia, PA 19104, USA. buck@wista.wistar.upenn.edu

Cell Adhesion and Communication
|August 1, 1996
PubMed
Summary

This study reveals dynamic receptor expression during mouse lung development, suggesting both angiogenesis and vasculogenesis contribute to vascular growth. Thrombomodulin

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Area of Science:

  • Developmental Biology
  • Immunohistology
  • Molecular Biology

Background:

  • Understanding lung development is crucial for addressing congenital lung diseases.
  • The roles of specific cell adhesion molecules and receptors in lung morphogenesis are not fully elucidated.

Purpose of the Study:

  • To investigate the dynamic expression patterns of various cell surface receptors during mouse lung development.
  • To explore the potential roles of angiogenic and vasculogenic processes in pulmonary vascular expansion.
  • To differentiate receptor expression between vascular and airway smooth muscle.

Main Methods:

  • Immunohistological analysis of mouse lung development using monoclonal antibodies.
  • Detection of endothelial cell markers (PECAM-1, factor VIII), smooth muscle markers (alpha-smooth muscle actin), adhesion receptors (ICAM-1, ICAM-2, VCAM-1, alpha 4, alpha 6 integrins), and endothelial cell function markers (thrombomodulin).

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Main Results:

  • Dynamic receptor expression patterns were observed throughout lung development.
  • Pulmonary vascular system expansion appears to involve both angiogenesis and vasculogenesis.
  • Differences in receptor expression were noted between vascular and airway smooth muscle.
  • ICAM-1 was predominantly extravascular during development.
  • Alpha 4 integrin and VCAM-1 expression lacked expected complementarity.
  • Thrombomodulin expression, localized to airway branching sites, suggests a key role in branching morphogenesis.

Conclusions:

  • Receptor expression dynamics provide insights into mouse lung vascularization and airway development.
  • The thrombin/thrombomodulin system likely plays a critical regulatory role in airway branching morphogenesis.