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Immunhistological evaluation of Creutzfeldt-Jakob disease with reference to the type PrPres deposition
J Tateishi1, T Kitamoto, H Kretzschmar
1Department of Neuropathology, Neurological Institute Kyushu University, Fukuoka, Japan.
Clinical Neuropathology
|November 1, 1996
Abstract:
German patients suspected of having Creutzfeldt-Jakob disease (CJD) and related diseases were studied pathologically. The immunohistochemical findings after hydrolytic autoclaving pretreatment sensitively detected the synaptic-type deposition of the protease-resistant isoform of the prion protein (PrPres which thus served to establish the consensus diagnosis of CJD.